Accumulation of cyclin B1, activation of cyclin B1-dependent kinase and induction of programmed cell death in human epidermoid carcinoma KB cells treated with taxol

1998 ◽  
Vol 75 (6) ◽  
pp. 925-932 ◽  
Author(s):  
Yi-He Ling ◽  
Ugo Consoli ◽  
Carmen Tornos ◽  
Michael Andreeff ◽  
Roman Perez-Soler
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Cyclin B1 ◽  
Epidermoid Carcinoma ◽  
Kb Cells ◽  
Human Epidermoid Carcinoma

scholarly journals Mitochondrial Pathway of α-Tocopheryl Succinate-Induced Apoptosis in Human Epidermoid Carcinoma A431 Cells

Acta Naturae ◽  
2012 ◽  
Vol 4 (3) ◽  
pp. 88-94 ◽  
Author(s):  
M. A. Savitskaya ◽  
M. S. Vildanova ◽  
O. P. Kisurina-Evgenieva ◽  
E. A. Smirnova ◽  
G. E. Onischenko
Keyword(s):  
Cell Death ◽  
Vitamin E ◽  
Apoptotic Cell ◽  
Mitochondrial Pathway ◽  
Epidermoid Carcinoma ◽  
A431 Cells ◽  
Human Carcinoma ◽  
Tocopheryl Succinate ◽  
Induced Apoptosis ◽  
Human Epidermoid Carcinoma

Vitamin E derivatives are known to act as agents exhibiting cytotoxity against tumor cells. The effect of vitamin E succinate on human epidermoid carcinoma cell line A431 was investigated in this study using live imaging, immunocytochemistry, and transmission electron microscopy. -Tocopheryl succinate-induced apoptotic cell death in A431 cells was shown to be both dose- and time-dependent. The hyperproduction of reactive oxygen species, changes in size, shape and ultrastructural characteristics of mitochondria followed by the release of cytochrome c from mitochondria to cytosol were observed. These results suggest that -tocopheryl succinate induces apoptosis that occurs via the mitochondrial pathway. Mitochondria are shown to be crucial targets in -tocopheryl succinate-induced caspase-dependent cell death in human carcinoma A431 cells.

α-interferon potentiates epidermal growth factor receptor-mediated effects on human epidermoid carcinoma KB cells

1995 ◽  
Vol 61 (3) ◽  
pp. 342-347 ◽  
Author(s):  
Michele Caraglia ◽  
Annalisa Leardi ◽  
Stefania Corradino ◽  
Fortunato Ciardiello ◽  
Alfredo Budillon ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Epidermoid Carcinoma ◽  
Kb Cells ◽  
Mediated Effects ◽  
Epidermal Growth ◽  
Human Epidermoid Carcinoma
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